Abstinence following Alcohol Drinking Produces Depression-Like Behavior and Reduced Hippocampal Neurogenesis in Mice
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چکیده
منابع مشابه
Running Head: Hippocampal Neurogenesis and Pain Behavior Alterations in Hippocampal Neurogenesis and Pain Behavior in Mice: An Experimental Study
As living condition has been shown to affect rates of neurogenesis, the current study was designed to examine the relationship between neurogenesis and pain behavior, particularly stressinduced analgesia (SIA) and tonic pain. Mice received daily injection stress and were placed in group or isolated housing conditions, with or without access to a running wheel in order to differentially manipula...
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Depression is a serious mental disorder that affects a person's mood, thoughts, behavior, physical health, and life in general. Despite our continuous efforts to understand the disease, the etiology of depressive behavior remains perplexing. Recently, aberrant early life or postnatal neurogenesis has been linked to adult depressive behavior; however, genetic evidence for this is still lacking. ...
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Adult neurogenesis is a newly considered form of plasticity that could contribute to brain dysfunction in psychiatric disease. Chronic alcoholism, a disease affecting over 8% of the adult population, produces cognitive impairments and decreased brain volumes, both of which are partially reversed during abstinence. Clinical data and animal models implicate the hippocampus, a region important in ...
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ژورنال
عنوان ژورنال: Neuropsychopharmacology
سال: 2008
ISSN: 0893-133X,1740-634X
DOI: 10.1038/npp.2008.90